IMMUNODOMINANT EPITOPES OF MYELIN PROTEINS, MBP MOG AND PLP CONJUGATED TO REDUCED OR OXIDIZED MANNAN VIA [(LYS-GLY)N] BRIDGE FOR THE TREATMENT OF MULTIPLE SCLEROSIS.

摘要

A first aspect of the invention relates to a conjugate comprising: (i) mannan; and (ii) at least one epitope or its cyclic counterpart of a protein selected from myelin basic protein (MBP), myelin oligodentrocyte glycoprotein (MOG) and proteolipid protein (PLP); wherein said epitope is linked to mannan via a [(Lys-Gly)n] bridge, where &eegr; is an integer from 1 to 10. Further aspects of the invention relate to pharmaceutical compositions comprising said conjugates, and their use in the preparation of a medicament for treating an immune disorder.