发明名称 |
STRATEGY FOR CLONING AND EXPRESSING THE EXTRACELLULAR DOMAINS OF RECEPTORS AS SOLUBLE PROTEINS |
摘要 |
The present invention relates generally to soluble G protein-coupled receptor constructs. More specifically, the invention relates to soluble chemokine receptors, and soluble HIV co-receptors in particular. The invention is generally useful for designing and constructing soluble GPCR, which may be used to identify binding molecules. The invention also relates to methods of treating and/or preventing a disease or disorder associated with impaired function of such a receptor. The invention thus provides compositions and methods for therapeutic applications, such as vaccine.
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申请公布号 |
US2010249022(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
US20080600785 |
申请日期 |
2008.05.15 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
CLAPHAM PAUL;REPIK ALEXANDER |
分类号 |
A61K38/16;A61P27/02;A61P31/18;A61P35/00;C07H21/04;C07K14/00;C07K16/00;C12N5/02;G01N33/53 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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