发明名称 |
LABELED ENZYME COMPOSITIONS, METHODS & SYSTEMS |
摘要 |
Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are labeled polymerase conjugates including a polymerase linked to one or more labels, wherein the conjugate has polymerase activity. Such conjugates can exhibit enhanced biological activity and/or superior detectability as compared to conventional labeled polymerases. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing. |
申请公布号 |
WO2010111686(A2) |
申请公布日期 |
2010.09.30 |
申请号 |
WO2010US28967 |
申请日期 |
2010.03.26 |
申请人 |
LIFE TECHNOLOGIES CORP;NIKIFOROV, THEO |
发明人 |
NIKIFOROV, THEO |
分类号 |
C12Q1/48;C12N9/12;G01N33/573;G01N33/58 |
主分类号 |
C12Q1/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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