METHOD AND DEVICE FOR RECONSTRUCTING A FLUORESCENCE IMAGE OF THE INTERIOR OF A TURBID MEDIUM

摘要

A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. Initial Green's functions for the light propagation in the turbid medium for irradiation light are calculated from the diffusion equation based on an initial assumption for the optical properties of the turbid medium. Optical properties are reconstructed as a function of the position in the interior of the turbid medium based on the results of an attenuation measurement. Updated Green's functions for the light propagation in the turbid medium for irradiation light are calculated from the diffusion equation based on the reconstructed optical properties of the turbid medium. Updated Green's functions for the light propagation in the turbid medium for fluorescence light are calculated from the diffusion equation based on the reconstructed optical properties of the turbid medium and based on an assumed contrast agent distribution. The spatial distribution of a fluorescent contrast agent is reconstructed based on the results of the fluorescence measurement. Updated Green's functions for the light propagation in the turbid medium for fluorescence light are calculated from the diffusion equation based on the reconstructed optical properties of the turbid medium and based on the reconstructed spatial distribution of the contrast agent. An updated spatial distribution of the fluorescent contrast agent is reconstructed based on the results of the fluorescence measurement.