OMENTUM AS A SOURCE OF STROMAL/STEM CELLS AND MEDICAL TREATMENTS USING OMENTUM STROMAL/STEM CELLS

摘要

Methods for generating and using omentum cells, particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, immune modulation treatments such as suppression of immune responses and inflammation/prevention of tissue fibrosis. A medical procedure is performed on a patient involving harvesting omental tissue from the patient, then transferring the omental tissue to an organ of the patient. A portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. The transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing a portion of the harvested omental tissue. The invention also encompasses a medical procedure comprising the transfer of omental stem cells to a patient, and a procedure comprising in vitro activation of omental stem cells by T cells to enhance immunomodulatory functions of the omental stem cells.