| 摘要 |
Disclosed are N-(1-phenyl-1-oxo-butan-4-yl)-4-hydroxy-4-(4-chlorophenyl)-piperazine derivatives as represented by the general formula (I), wherein R1 is selected from the group consisting of alkoxy, fluoro-alkoxy and OH; and R2 is selected from the group consisting of H and fluoro; and pharmaceutically acceptable acid addition salts and solvates thereof. Of particular importance are the compounds 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(3-methoxyphenyl)butan-l-one; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(3-trifluoromethoxyphenyl)butan-1-one; and 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(3-ethoxyphenyl)butan-1-one. Also disclosed is the use of a compound as defined above in the manufacture of a medicament in the treatment of psychosis in a subject.
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