发明名称 |
Substituted Heteroarylpiperidine Derivatives As Melanocortin-4 Receptor Modulators |
摘要 |
The present invention relates to substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators. Depending on the structure and the stereochemistry the compounds of the invention are either selective agonists or selective antagonists of the human melanocortin-4 receptor (MC-4R). The agonists can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, amyotrophic lateral sclerosis (ALS), anxiety and depression. Generally all diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.
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申请公布号 |
US2010249093(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
US20080665771 |
申请日期 |
2008.07.18 |
申请人 |
SANTHERA PHARMACEUTICALS (SCHWEIZ) AG |
发明人 |
HENNEBOEHLE MARCO;HERZNER HOLGER;SOEBERDT MICHAEL;WEYERMANN PHILIPP;NORDHOFF SONJA;FEURER ACHIM;DEPPE HOLGER;SIENDT HERVE;TERINEK MIROSLAV;RUMMEY CHRISTIAN |
分类号 |
A61K31/397;A61K31/4545;A61K31/496;A61K31/553;A61P3/04;A61P3/10;A61P15/00;A61P25/22;A61P35/00;C07D401/14;C07D403/14;C07D413/14 |
主分类号 |
A61K31/397 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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