N-( 5-Hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-caboxamide

摘要

Disclosed are 4-oxo-quinoline-3-carboxamide derivatives of general formula (I), wherein the substituents are as defined herein. Of particular importance is the compound N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-caboxamide, or a pharmaceutically acceptable salt thereof. Also disclosed is a pharmaceutical composition comprising a compound as defined above and a pharmaceutically acceptable carrier or adjuvant. Further disclosed is the use of a compound or composition as described above in the manufacture of a medicament for treating or lessening the severity of cystic fibrosis in a patient (wherein the patient may possess a cystic fibrosis transmembrane receptor (CFTR)).