N-dihydroxyalkyl-substituted 2-oxo-imidazole (benzimidazolone) derivatives

摘要

Disclosed is a piperidine-substituted benzimidazolone derivative of formula (I), wherein R is a di-hydroxy-substituted C1-6alkyl, and Cy is a spiro or bridged hydrocarbon ring group selected from the list given in the specification. Also described is the use of a compound as an analgesic, a reliever against tolerance to narcotic analgesics, a reliever against dependence on narcotic analgesics or against addiction, an analgesic enhancer; an antiobestic or appetite suppressor, or for treating cognitive impairment and dementia/amnesia in aging, cerebrovascular disease and Alzheimer's disease, developmental cognitive abnormality in attention deficit, hyperactivity disorder and learning disability, schizophrenia, neurodegenerative diseases such as Parkinsonism and chorea, affective disorder, diabetes insipidus, polyuria, or hypotension.