发明名称 |
PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES |
摘要 |
The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5- (aryl-sulfonyl)-4,5-dihydro- 1H-pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5- dihydro-1H-pyrazolo[4,3-c]quinolines. Exemplary methods of the invention include an intra-molecular cyclization step, in which a carbon-nitrogen bond is formed, and which employs a copper-based catalyst that contains at least one organic ligand, such as DMEDA. The invention further provides compounds, which are useful as intermediates in the methods of the invention.
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申请公布号 |
CA2756064(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
CA20102756064 |
申请日期 |
2010.03.24 |
申请人 |
ELAN PHARMACEUTICALS, INC. |
发明人 |
DAPPEN, MICHAEL S.;JAGODZINSKI, JACEK J.;LATIMER, LEE H.;WU, JING;GODFREY, JOLLIE DUAINE, JR.;MATUNAS, ROBERT M.;DRABB, THOMAS W.;PROBST, GARY D. |
分类号 |
C07D231/12;A61K31/437;C07D231/16;C07D471/04 |
主分类号 |
C07D231/12 |
代理机构 |
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