发明名称 |
MEMBRANE EVAPORATION FOR GENERATING HIGHLY CONCENTRATED PROTEIN THERAPEUTICS |
摘要 |
The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the invention include membrane evaporation, such as evaporation of protein-free solvent from the protein solution, which concentrates the protein. The methods of the present invention result in protein solution concentrations not previously achievable by conventional ultrafiltration methods, e.g., protein solution concentrations of greater than about 260 grams of protein per liter of solution. |
申请公布号 |
WO2010111378(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
WO2010US28486 |
申请日期 |
2010.03.24 |
申请人 |
WYETH LLC;BOLTON, GLEN, REED;ACHARYA, HARI;BOESCH, AUSTIN, WAYNE |
发明人 |
BOLTON, GLEN, REED;ACHARYA, HARI;BOESCH, AUSTIN, WAYNE |
分类号 |
B01D61/24;A61K39/395;B01D61/36;C07K16/06 |
主分类号 |
B01D61/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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