发明名称 |
NOVEL PRODRUGS |
摘要 |
<p>The present invention relates to novel prodrug compounds, or pharmaceutically acceptable salts thereof, which convert in vivo to the active species 4-(1-benzenesulfonyl-6-fluoro-1H-indol-2-yl)-4-hydroxy-cyclohexa-2,5-dienone. The prodrug compounds of the invention have dramatically improved solubility relative to 4-(1-benzenesulfonyl-6-fluoro-1H- indol-2-yl)-4-hydroxy-cyclohexa-2,5-dienone and, accordingly, can be easily formulated for administration to a patient. The prodrugs of the invention are therefore useful for the treatment cellular proliferation disorders, such as cancer.</p> |
申请公布号 |
WO2010109230(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
WO2010GB50490 |
申请日期 |
2010.03.24 |
申请人 |
PHARMINOX LIMITED;WELLS, GEOFFREY;MCCARROLL, ANDREW JAMES;STEVENS, MALCOLM FRANCIS GRAHAM |
发明人 |
WELLS, GEOFFREY;MCCARROLL, ANDREW JAMES;STEVENS, MALCOLM FRANCIS GRAHAM |
分类号 |
C07D209/12;A61K31/404;A61P35/00 |
主分类号 |
C07D209/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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