发明名称 |
DSRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTIONS |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
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申请公布号 |
US2010249052(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
US20080593202 |
申请日期 |
2008.03.25 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
BENSON JOHN;FITZGERALD KEVIN;BRAMLAGE BIRGIT;TAN PAMELA;VORNLOCHER HANS-PETER |
分类号 |
C12N15/86;A61K31/7088;C07H21/02;C12N15/113 |
主分类号 |
C12N15/86 |
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