发明名称 |
EXPRESSION TECHNOLOGY FOR PROTEINS CONTAINING A HYBRID ISOTYPE ANTIBODY MOIETY |
摘要 |
Disclosed are methods and compositions for efficiently expressing antibody fusion proteins. Antibody fusion proteins of the invention include a hybrid antibody moiety containing sequences from more than one type of antibody and/or mutant antibody sequences. Hybrid antibody fusion proteins of the invention may be produced at high levels and may combine functional properties characteristic of different antibody types in addition to functional properties of a non-antibody moiety. |
申请公布号 |
PL206701(B1) |
申请公布日期 |
2010.09.30 |
申请号 |
PL20020366981 |
申请日期 |
2002.03.07 |
申请人 |
MERCK PATENT GMBH |
发明人 |
GILLIES STEPHEN D.;WAY JEFFREY;LO KIN-MING |
分类号 |
C07K16/46;C12N15/09;C07K14/505;C07K16/00;C07K16/30;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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