COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEOPLASTIC DISORDERS

摘要

Compositions for the treatment and/or prevention of cancer in a mammal by means of RNA interference are provided, together with methods for the use of such compositions. The compositions comprise a small interfering nucleic acid molecule (siNA) that suppresses expression of the YBX1 gene that is involved in RNA splicing and masking, translation, DNA repair and transcription.