| 摘要 |
The invention relates to in vitro methods for producing pancreatic progenitor cells and cell populations from cells having definitive endoderm germ layer phenotype. The invention further encompasses so-obtained pancreatic progenitor cells and cell populations, compositions comprising the same, and further uses of said pancreatic progenitor cells and cell populations, such as inter alia for producing functional, insulin-producing beta cells. The invention is of particular relevance for medical applications, more specifically in the field of cell therapy of diabetes.
|
