| 摘要 |
<p>#CMT# #/CMT# Biodegradable monophasic cohesive hydrogel comprises homogeneous mixture of identical or different x polymers cross-linked prior to their interpenetration by mixing in monophasic hydrogel form, where the crosslinked polymers are water insoluble and mixed between them, and x is 2-5. #CMT# : #/CMT# Independent claims are included for: (1) the preparation of the biodegradable cohesive monophasic hydrogel comprising crosslinking a first polymer at a rate of crosslinking x1, crosslinking of a second polymer at a rate of crosslinking x2, interpenetration by mixing of two polymers, hydration and final interpenetration by final mixing after hydration; and (2) a kit comprising the hydrogel packed in sterile syringe. #CMT#ACTIVITY : #/CMT# Dermatological. #CMT#MECHANISM OF ACTION : #/CMT# None given. #CMT#USE : #/CMT# The hydrogel is useful for the formulation of a viscosupplement composition, and for the formulation of a composition for the filling of wrinkles (all claimed), fine lines and skin defects. No biological data given. #CMT#ADVANTAGE : #/CMT# The hydrogel can be easily prepared with high viscosity and excellent rheological property. #CMT#PHARMACEUTICALS : #/CMT# Preferred Composition: The hydrogel optionally comprises one or more active ingredient comprising antioxidants, antiseptics, antiinflammatory and local anesthetics. The antioxidants are mannitol and/or sorbitol. Preferred Components: The local anesthetic is lidocaine. #CMT#POLYMERS : #/CMT# Preferred Process: The process further comprises x step for crosslinking of x polymers before the mixing of the crosslinked x polymer. The crosslinking is carried out by the action of a polyfunctional crosslinking agent comprising epoxy bi- or poly- functional group, divinyl sulfone, carbodiimide or formaldehylde. The crosslinking agents implemented in the crosslinking steps are identical or different. The rate of crosslinking x1 is greater than or equal to the rate of the crosslinking x2. The crosslinking rates are 0.02-0.4, preferably 0.08-0.2. Preferred Components: The polymers have different cross-linking rate; where at least one x-polymers have a rate of crosslinking x1, at least one of x polymers have a rate of crosslinking x2, and x1 is >= x2; and identical crosslinking rate. The polymers are polysaccharides. The polysaccharides are hyaluronic acid, cellulose and their derivatives, chondroitin, and chitosan (all preferred), keratan, heparin, alginic acid, xanthan and carrageenan and their biologically acceptable salts. In the hydrogel, x is 2. The first x polymer is hyaluronic acid and the second is chondroitin sulfate or its salts, chitosan or its salts and derivatives, cellulose derivatives and their salts and alginic acid. The first x polysaccharide is hyaluronic acid or its salts, cellulose derivatives and their salts and xanthan, and the second is chondroitin sulfate or its salts, chitosan or its salts and derivatives, cellulose derivatives and their salts and alginic acids. #CMT#ADMINISTRATION : #/CMT# Administration of the hydrogel is by injection e.g. intradermal, intraarticular or intraperitoneal. No dosage details given. #CMT#EXAMPLE : #/CMT# Injectable sodium hyaluronate fiber (1 g, having a molecular mass of 2.7 MDa) was weighed into a container. Sodium hydroxide aqueous solution in 1% water was added, then the mixture was homogenized for one hour at an ambient temperature to obtain non-crosslinked sodium hyaluronate gel. 1,4-Butanedioldiglycidylether (65 mg) was added to obtained sodium hyaluronate (NaHA) gel and homogenized for about 30 minutes at room temperature. The package was placed in a water bath at 50[deg] C for 2 hours 20 minutes to obtain rate of crosslinking x1 of 0.14. Then the final crosslinked gel was then neutralized by adding hydrochloric acid (1N) and placed in a phosphate buffer bath to stabilize the pH and to allow hydration to obtain the hydrogel.</p> |
