发明名称 |
Specific amplification of tumor specific DNA sequences |
摘要 |
The present invention provides methods for cancer detection and diagnosis. The present invention provides a method of selectively amplifying hypomethylated tumor DNA sequences derived from a subject for detection of cancer. This method utilizes differential methylation to allow for the selective amplification of tumor specific sequences from DNA mixtures that contain a high proportion of normal host DNA. The invention also provides methods of using the amplified tumor DNA sequences for evaluation of methylation. |
申请公布号 |
ZA201000209(B) |
申请公布日期 |
2010.09.29 |
申请号 |
ZA20100000209 |
申请日期 |
2010.01.12 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
BROWN, STEPHEN, A |
分类号 |
C12Q |
主分类号 |
C12Q |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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