GENETIC MARKERS FOR THE PROGNOSIS OF MULTIPLE SCLEROSIS
摘要
<p>The present invention relates to a series of genes the expression of which is altered in subjects suffering multiple sclerosis with respect to healthy subjects or in subjects suffering multiple sclerosis with a good prognosis with respect to subjects suffering multiple sclerosis with a bad prognosis. A subset formed by 13 genes and two clinical variables which allows predicting the progress of a patient with a high reliability has been validated from an initial set of genes which showed said differential expression. From said expression values, the invention provides methods for predicting the progress of a patient diagnosed with multiple sclerosis from tables of conditional probability between the expression levels of a determined gene or group of genes and the probability that the patient has a good or bad prognosis of the disease.</p>
申请公布号
EP2233586(A2)
申请公布日期
2010.09.29
申请号
EP20080865077
申请日期
2008.12.18
申请人
INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A;PROGENIKA BIOPHARMA, S.A.