发明名称 |
Gastrin compositions and formulations, and methods of use and preparation |
摘要 |
The present invention concerns six novel variants of alternative splicing of the CD40 receptor The invention provides a pharmaceutical composition comprising a gastrin compound having an extended activity upon administration to a subject in comparison with native gastrin. Methods are provided of conjugating portions of the amino acid sequence of gastrin having functional ability to bind to the gastrin/CCK receptor, to various carrier moieties, including the use of amino acid spacer regions, and use of bifunctional cross-linking reagents. Methods of treating a diabetes patient with the compositions are provided.
|
申请公布号 |
US7803766(B2) |
申请公布日期 |
2010.09.28 |
申请号 |
US20070701196 |
申请日期 |
2007.01.31 |
申请人 |
WARATH PHARMACEUTICALS, INC |
发明人 |
CRUZ ANTONIO |
分类号 |
A61K38/16;A61K45/06;A61K;A61K31/133;A61K31/135;A61K31/136;A61K31/14;A61K31/343;A61K31/436;A61K31/519;A61K31/52;A61K31/573;A61K31/675;A61K38/00;A61K38/08;A61K38/10;A61K38/18;A61K38/21;A61K38/22;A61K38/28;A61K39/385;A61K39/395;A61K48/00;A61P3/10;A61P37/06;A61P43/00;C07K14/00;C07K14/595 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|