METHOD FOR MANUFACTURE OF ESCITALOPRAM

摘要

This patent discloses a method for resolution of 4-¬4-(dimethylamino)- 1-(4'-fluorophenyl)-1-hydroxybutyl|-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallising 4-¬4-(dimethylamino)-1-(4'- fluoro- phenyl)-1-hydroxybutyl|-3-(hydroxymethyl)-benzonitrile as a salt with the (+)- (S,S)- or (-)-(R,R)-enantiomer of O, O'-di-p-toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile.