发明名称 |
Combined use of enzyme inhibitors and of pharmaceutical compositions thereof |
摘要 |
Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) and use of the same to obtain a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.
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申请公布号 |
US7803776(B2) |
申请公布日期 |
2010.09.28 |
申请号 |
US20070811565 |
申请日期 |
2007.06.11 |
申请人 |
INSTITUT FUR MEDIZINTECHNOLOGIE MAGDEBURG (IMTM) GMBH |
发明人 |
ANSORGE SIEGFRIED;LENDECKEL UWE;NEUBERT KLAUS;REINHOLD DIRK;VETTER ROBERT;GOLLNICK HARALD |
分类号 |
A61K31/40;C12N9/99;A61K31/662;A61K38/05;A61K38/07;A61K38/55;A61K45/00;A61P9/10;A61P17/00;A61P17/06;A61P35/00;A61P37/06;A61P37/08 |
主分类号 |
A61K31/40 |
代理机构 |
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