发明名称 |
Method for screening human intestinal Npt2B modulatory agents |
摘要 |
A novel human sodium phosphate cotransporter expressed on the apical surface of intestinal epithelial cells (huNpt2B) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting Npt2B activity in a host and methods of treating disease conditions associated with Npt2B activity.
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申请公布号 |
US7803562(B2) |
申请公布日期 |
2010.09.28 |
申请号 |
US20070002624 |
申请日期 |
2007.12.18 |
申请人 |
ROCHE PALO ALTO LLC |
发明人 |
CANNON PAUL DAVID;SANKURATRI SURYANARAYANA |
分类号 |
A01K67/027;G01N33/53;A01K67/02;A61K31/00;A61K38/00;A61K38/16;A61K38/17;A61K39/395;A61K45/00;A61P1/00;A61P3/00;A61P3/02;A61P3/12;A61P3/14;A61P7/08;A61P13/02;A61P13/12;A61P19/00;A61P19/08;A61P43/00;C07H21/00;C07H21/04;C07K;C07K14/245;C07K14/435;C07K14/47;C07K16/18;C07K16/28;C07K16/42;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12N15/63;C12P21/02;C12P21/08;C12Q1/02;C12Q1/68;C12R1/91;G01N33/15;G01N33/50;G01N33/531;G01N33/577;G01N33/58;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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