2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE

摘要

A glucokinase activator is provided, and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt. (see formula I-0) [in the formula, X represents a carbon atom or a nitrogen atom, X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom, the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II) (see formula II) (in the formula, X represents a carbon atom or a nitrogen atom), R1 represents an aryl, etc , R2 represents a hydroxy, etc , R3 represents a -C1-6 alkyl, etc ; R4 represents a -C1-6 alkyl, etc , X5 represents -O-, etc , a indicates an integer of 1, 2 or 3, q indicates an integer of from 0 to 2, m indicates an integer of from 0 to 2].