发明名称 |
NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS |
摘要 |
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR)(NR1H3) and/or(NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them. |
申请公布号 |
UA91992(C2) |
申请公布日期 |
2010.09.27 |
申请号 |
UA20070007236 |
申请日期 |
2006.01.09 |
申请人 |
ASTRAZENECA AB |
发明人 |
BROO ANDERS;HOLM PATRIK;JUDKINS ROBERT;LI LANNA;LINDSTEDT-ALSTERMARK EVA-LOTTE;SANDBERG PERNILLA;SWANSON MARIANNE;WEIDOLF LARS;BRICKMANN KAY |
分类号 |
A61K31/425;A61K31/427;A61K31/4427;A61K31/454;A61K31/506;A61K31/5377;A61P3/06;A61P3/10;A61P9/10;A61P25/28;C07D;C07D275/02;C07D275/03;C07D417/12;C07D417/14 |
主分类号 |
A61K31/425 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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