| 发明名称 |
METHOD FOR PRODUCING 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)PENTAN-2-OL DERIVATIVE |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for producing a 1,1,1-trifluoro-4-phenyl-4-methyl-2-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-ol derivative. <P>SOLUTION: The method of production involves (a) a process for forming a diol by reacting an ester with a suitable reductant in a suitable solvent, (b) a process for forming the ketone of formula (IV) by reacting the diol under suitable conditions for oxidative decomposition, and (c) a process for forming the compound of formula (IA) by reacting the ketone of formula (IV) with the suitable organometallic reagent, R<SP>5</SP>R<SP>4</SP>M (M is Li or MgX; and X is Cl, Br or I), in a suitable solvent. <P>COPYRIGHT: (C)2010,JPO&INPIT</p> |
| 申请公布号 |
JP2010209100(A) |
申请公布日期 |
2010.09.24 |
| 申请号 |
JP20100106594 |
申请日期 |
2010.05.06 |
| 申请人 |
BOEHRINGER INGELHEIM PHARMACEUTICALS INC |
发明人 |
BEKKALI YOUNES;BETAGERI RAJASHEKHAR;EMMANUEL MICHAEL J;HAMMACH ABDELHAKIM;HARCKEN CHRISTIAN H J J;KIRRANE THOMAS MARTIN;KUZMICH DANIEL;LEE THOMAS WAI-HO;LIU PINGRONG;PATEL USHA R;RAZAVI HOSSEIN;RIETHER DORIS;TAKAHASHI SHUSUKE;THOMSON DAVID S;WANG JI;ZINDELL RENEE;PROUDFOOT JOHN ROBERT |
| 分类号 |
C07D209/12;A61K31/381;A61K31/404;A61K31/4045;A61K31/405;A61K31/4355;A61K31/4365;A61K31/437;A61K31/44;A61K31/4409;A61K31/4439;A61K31/444;A61K31/454;A61K31/455;A61K31/47;A61K31/4725;A61K31/4745;A61K31/496;A61K31/5025;A61K31/506;A61K31/519;A61K31/52;A61K31/5377;A61P1/04;A61P1/16;A61P3/04;A61P3/10;A61P5/44;A61P5/46;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/06;A61P19/00;A61P19/02;A61P19/08;A61P21/00;A61P25/00;A61P25/04;A61P25/28;A61P27/06;A61P29/00;A61P35/00;A61P37/02;A61P37/06;A61P37/08;C07B61/00;C07D209/08;C07D213/30;C07D213/61;C07D213/75;C07D213/84;C07D213/85;C07D215/14;C07D215/18;C07D215/22;C07D231/56;C07D235/08;C07D237/20;C07D239/42;C07D307/79;C07D319/06;C07D319/08;C07D333/56;C07D401/06;C07D401/10;C07D403/06;C07D403/10;C07D405/04;C07D405/06;C07D405/10;C07D405/14;C07D407/06;C07D471/02;C07D471/04;C07D487/04;C07D491/02;C07D491/04;C07D491/048;C07D495/04;C07D498/02 |
主分类号 |
C07D209/12 |
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