| 摘要 |
A pharmaceutical composition containing as active ingredient a therapeutically effective amount of a derivative of the retinoids having general Formula (I) wherein : R represents H or adamantyl; R' represents OR"'; R" represents, COOH, COO RIV CONHOH, CONH, CONH RIV; R"' represents H or alkyl,; RVI represents H or alkyl; its optically active forms such as enantiomers, diastereoisomers and its racemate forms, as well as pharmaceutically acceptable salts, and the proteasome inhibitor bortezomib, for the treatment of ovarian carcinoma, drug-resistant forms included. The compounds according to the present invention can be administrated in a co-ordinated or combined manner. The combination is also used for the preparation of a medicament for the treatment of ovarian carcinoma.
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