发明名称 |
MIRNAS AS THERAPEUTIC TARGETS IN CANCER |
摘要 |
<p>Methods for modulating expression of a component of a cell, comprising contacting the cell with a nucleic acid comprising an miR-140 nucleic acid sequence in an amount sufficient to modulate the cellular component are provided. Overexpression of miR-140 inhibits cell proliferation in both U-2 OS (wt-p53) and HCT 116 (wt-p53) cell lines. Cells transfected with miR-140 are more resistant to chemotherapeutic agent methotrexate, mi- 140 expression is related to HDAC4 protein expression. The claimed methods reduce the protein expression level of HDAC4 without degrading the target mRNA.</p> |
申请公布号 |
WO2010108192(A1) |
申请公布日期 |
2010.09.23 |
申请号 |
WO2010US28191 |
申请日期 |
2010.03.22 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;JU, JINGFANG;WANG, YUAN;SONG, BO |
发明人 |
JU, JINGFANG;WANG, YUAN;SONG, BO |
分类号 |
C12Q1/68;A61K31/7088;C07H21/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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