COMPOSITIONS AND METHODS FOR BLOOD-BRAIN BARRIER DELIVERY OF IGG-DECOY RECEPTOR FUSION PROTEINS
摘要
Provided herein are compositions and related methods for delivering an IgG-decoy receptor to the CNS. The methods include systemic administration of a bifunctional decoy receptor-BBB receptor antibody fusion antibody comprising a receptor extracellular domain (ECD) covalently linked to an antibody to a receptor expressed on the surface of the blood-brain barrier (BBB receptor). In some embodiments, the compositions described herein are administered to treat a subject suffering from a CNS condition.
申请公布号
WO2010108048(A2)
申请公布日期
2010.09.23
申请号
WO2010US27882
申请日期
2010.03.18
申请人
ARMAGEN TECHNOLOGIES, INC.;PARDRIDGE, WILLIAM, M.;BOADO, RUBEN, J.