发明名称 |
IN VITRO METHODS FOR DETERMINING AN INTRACELLULAR FREE MAGNESIUM DEFICIENCY OF INDIVIDUALS BY DETERMINING THE EXPRESSION RATE OF A CELLULAR MG2+ TRANSPORTER GENE |
摘要 |
An in vitro method is disclosed for determining the presence or absence of an intracellular free magnesium deficiency in a human individual by determining the expression rate of at least one cellular Mg2+ transporter gene showing a direct correlation between its expression rate and the intracellular free magnesium ion concentration [Mg2+]i in a cell sample of said individual and comparing the obtained expression rate with a reference value, wherein an increase of the expression rate relative to the reference value indicates that the individual suffers from an intracellular free magnesium deficiency. Suitable Mg2+ transporter genes include CNNM2, SLC41A1 and SLC41A3. |
申请公布号 |
WO2010105724(A1) |
申请公布日期 |
2010.09.23 |
申请号 |
WO2010EP01012 |
申请日期 |
2010.02.17 |
申请人 |
PROTINA PHARMAZEUTISCHE GESELLSCHAFT MBH;KOLISEK, MARTIN;VORMANN, JUERGEN |
发明人 |
KOLISEK, MARTIN;VORMANN, JUERGEN |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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