发明名称 |
INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF |
摘要 |
The present invention relates to inhibitors of MALT1 proteolytic and/or autoproteolytic activity. More specifically, it relates to compounds such as, but not limited to peptide derivates such as Z-LSSR-CHO, Z-LSSR-CMK, Z-GASR-CHO, and Z-GASR-CMK, and small compounds such as 5-{[5-(3-chloro-4-methylphenyl)-2-furyl]methylene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione and variants thereof, and the use of those compounds for the preparation of a medicament. The invention relates further to a method to screen for inhibitors of the MALT1 proteolytic and/or autoproteolytic activity. |
申请公布号 |
WO2009065897(A3) |
申请公布日期 |
2010.09.23 |
申请号 |
WO2008EP65925 |
申请日期 |
2008.11.20 |
申请人 |
VIB VZW;UNIVERSITEIT GENT;KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R & D;BEYAERT, RUDI;MARYNEN, PETER;BAENS, THIJS;HEYNINCK, KAREN |
发明人 |
BEYAERT, RUDI;MARYNEN, PETER;BAENS, THIJS;HEYNINCK, KAREN |
分类号 |
A61K38/07;A61K31/513;C07D405/06 |
主分类号 |
A61K38/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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