Method for selecting a candidate drug compound

摘要

The invention relates to the field of candidate drug testing and drug development. The invention provides a method for selecting a candidate drug compound from among a library of compounds wherein binding of a target molecule is determined with said candidate compound bound to a solid support and also is determined with said candidate compound not bound to a solid support said method comprising selecting said candidate compound from among compounds composed of an invariant scaffold molecule to which a variant potential binding site molecule is linked. Furthermore, the invention relates to methods for attaching molecules to a scaffold. In particular, the invention relates to the synthesis of discontinuous or conformational binding sites or epitopes corresponding to or interacting with a binding molecule, in particular in relation to protein-protein or protein-ligand interactions.