<p>The present invention describes compositions and methods showing that the spatial proximity of intracellular components may be related to their ability to cooperate in intracellular biochemical reactions. In some embodiments, the present invention contemplates a variety of nucleic acid barcoded binding partners capable of determining the spatial proximity of intracellular components as determined by ligation of their respective nucleotide barcodes. As such, an intracellular component contact map may be constructed to fingerprint specific physiological and/or pharmacological intracellular conditions.</p>
申请公布号
WO2010107416(A1)
申请公布日期
2010.09.23
申请号
WO2009US01911
申请日期
2009.03.26
申请人
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;LIEBERMAN, EREZ;GNIRKE, ANDREAS;AIRD, DANIEL