ANTIBODY CONSTANT REGION VARIANT

摘要

Disclosed is a constant region which can grant an antibody desirable properties particularly as a pharmaceutical by means of an amino acid sequence modification. The disclosed variant constant region considerably decreases heterogeneity by being used in antibody production. Namely, by introducing the disclosed modification into the heavy-chain constant regions of an antibody, homogeneity of the antibody can be maintained at a high level. More concretely, it is possible to prevent a decrease in homogeneity caused by disulfide bond linkage differences in the heavy chain of an antibody molecule. Furthermore, in a preferred embodiment, it is possible to prevent a decrease in homogeneity caused by a C-terminal deletion in a constant region of an antibody, and to improve the pharmacokinetics of the antibody.