Method of sensing an analyte

摘要

A method of sensing an analyte in a fluid comprises: passing a fluid over a sensor array, the sensor array comprising at least one particle positioned within a cavity of a supporting member, wherein the particle comprises a polymeric resin and a receptor coupled to the polymeric resin; monitoring a spectroscopic change of the particles as the fluid is passed over the sensor array, wherein the spectroscopic change is caused by the interaction of the analyte with the particle.
The receptor can be an enzyme substrate and the analyte an enzyme such as protease, nuclease or glycosidase.