| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: in formula is or , is , R1 is hydrogen, halogen, nitro or amino, R2 is hydrogen or lower alkyl, R3 is hydrogen, -X- is where -Y- is a bond, -O-, -NH- or -CH2-, and R4, R5 and R6 each denotes hydrogen, R7 is (C1-C8)-alkyl, (C3-C8)-cycloalkyl, -Z-R9 or , where -Z- is -O- or -S-, and each R9 independently denotes (C1-C8)-alkyl, (C3-C8)-cycloalkyl, and R8 is -D-E-R10, in which -D- is -CONHSO2-, E is (C1-C6)-alkylene and R10 denotes -O-R11 in which R11 is hydrogen. The invention also relates to use of said compounds to prepare a medicinal agent, a pharmaceutical composition and a method of preventive and/or therapeutic treatment of overactive bladder and/or acraturesis. ^ EFFECT: derivatives are highly effective. ^ 7 cl, 56 ex |
