发明名称 |
ANTI MIF ANTIBODIES |
摘要 |
The present application relates to monoclonal antibodies and antigen-binding portions thereof, that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The application also relates to isolated heavy and light chain immunoglobulins derived from the anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present application also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions. |
申请公布号 |
KR20100102197(A) |
申请公布日期 |
2010.09.20 |
申请号 |
KR20107017306 |
申请日期 |
2008.12.30 |
申请人 |
BAXTER INTERNATIONAL INC.;DYAX CORP.;BAXTER HEALTHCARE S.A. |
发明人 |
KERSCHBAUMER RANDOLF;SCHEIFLINGER FRIEDRICH;RIEGER MANFRED;THIELE MICHAEL;MUDDE C. GEERT;MUELLBERG JUERGEN;HOET RENE |
分类号 |
C07K16/24;A61K39/395;A61P35/00;C12N15/13 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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