METHOD OF PREPARING NON-CRYSTALLINE (+)-LANSOPRAZOLE AND (+)-LANSOPRAZOLE ALCOHOLATE USED THEREIN

摘要

PURPOSE: A method for preparing amorphous (+)-lansoprazole and (+)-lansoprazole alcoholate used for the same are provided. CONSTITUTION: A method for preparing (+)-lansoprazole comprises: a step of crystallizing (+)-lasoprazole alcoholate of chemical formula 1 from alcohol solution of C1-C3; and a step of drying obtained (+)-lansoprazole alcoholate at room temperature to 50°C. In chemical formula 1, and R is alkyl group of C1-C3; n is 1.0+/-0.3. The R is ethyl group, 1-propyl group or 2-propyl group.