| 摘要 |
The present invention concerns a process for the preparation of a flexible composite membrane, biocompatible and biodegradable, obtained from natural or synthetic materials, containing inorganic osteoconductive elements with a gradient of concentration along the thickness of the membrane or an asymmetric concentration of such elements in both sides of the membrane. The membrane may be obtained by gravitational deposition of the osteoconductive elements during solvent evaporation. The membrane is aimed to be used in vivo, in guided tissue regeneration, as a sealant for defects or structures for tissue engineering, or as coatings for biomaterials. The membrane exhibits one side featuring osteoconductive properties, that interacts favorably with mineralized tissues or other implanted bioactive materials, and the other side prevents the penetration or invasion of other tissues. |
