发明名称 |
COMPOSITIONS AND METHODS FOR ELIMINATION OF GRAM-NEGATIVE BACTERIA |
摘要 |
<p>Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.</p> |
申请公布号 |
WO2010103119(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
WO2010EP53231 |
申请日期 |
2010.03.12 |
申请人 |
DA VOLTERRA;ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS;UNIVERSITE DENIS DIDEROT - PARIS 7;ANDREMONT, ANTOINE;DE GUNZBURG, JEAN;LESCURE, FRANCOIS |
发明人 |
ANDREMONT, ANTOINE;DE GUNZBURG, JEAN;LESCURE, FRANCOIS |
分类号 |
A61K31/357;A61K9/32;A61K9/58;A61K31/7036;A61K31/7052;A61K38/12;A61P31/04 |
主分类号 |
A61K31/357 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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