发明名称 |
ANTAGONIST OF FACTOR VIII INTERACTION WITH LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a usable Factor VIII preparation increasing the stability and half-life of Factor VIII in vitro and in vivo. <P>SOLUTION: The invention relates to the use of peptides derived from and antibodies generated against Factor VIII, and the inhibition of Factor VIII interaction with LRP. Further, the invention concerns a method for inhibiting LRP interaction with Factor VIII as well as a method for decreasing Factor VIII degradation, a method for prolonging Factor VIII half-life in a biological fluid and/or a method for treating patients suffering from a blood coagulation disorder (especially Haemophilia A). The invention also concerns a pharmaceutical composition useful for the decrease of Factor VIII degradation in the biological fluid, the inhibition of Factor VIII interaction with LRP, and/or the prolongation of Factor VIII half-life in the biological fluid for treatment of the blood coagulation disorder (especially Haemophilia A). <P>COPYRIGHT: (C)2010,JPO&INPIT |
申请公布号 |
JP2010202664(A) |
申请公布日期 |
2010.09.16 |
申请号 |
JP20100130425 |
申请日期 |
2010.06.07 |
申请人 |
STICHTING SANQUIN BLOEDVOORZIENING |
发明人 |
MERTENS KOENRAAD;BOVENSCHEN AREND NIELS;VOORBERG JAN;RIEGER MANFRED;SCHEIFLINGER FRIEDRICH |
分类号 |
A61K39/395;C12N15/09;A61K38/00;A61K39/00;A61P7/02;A61P7/04;A61P41/00;A61P43/00;C07K14/755;C07K16/36 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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