发明名称 |
Method of surface coating devices to incorporate bioactive molecules |
摘要 |
A first embodiment is a coating for a surface comprising an electrostatic self-assembly creating one or more coating layer(s); (i) wherein one or more high molecular weight bioactive molecule(s) is bound to a protein carrier wherein said protein carrier or said bound bioactive molecule is further bound to one or more of said coating layer(s) and/or (ii) wherein one or more low molecular weight bioactive molecule(s) is/are incorporated within one or more of said layers or later introduced to said layer or layers by post-treatment. A second embodiment is a method of coating a surface comprising introducing said surface into a solution of one or more positively charged water-soluble polyelectrolytes at a pH ranging from about 2 to about 12 and at a temperature ranging from about 4° C. to about 80° C. and incubating said surface for about 0.5 to about 60 minutes; Rinsing said surface with said buffer solution or water to remove weakly bound material on said surface and dry by means known to one skilled in the art; Introducing said surface into a solution of one or more negatively charged water-soluble polyelectrolytes at a pH ranging from about 2 to about 12 and at a temperature ranging from about 4° C. to about 80° C. and incubating said surface for about 0.5 to about 60 minutes; and Rinsing said surface with said buffer solution or water to remove weakly bound material on said surface and passively or actively drying said surface.
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申请公布号 |
US2010233225(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
US20080069526 |
申请日期 |
2008.02.11 |
申请人 |
LI BINGYUN |
发明人 |
LI BINGYUN |
分类号 |
A61K9/00;A61K31/7048;A61K31/7088;A61K35/00;A61K38/00;A61K38/19;A61K38/20;A61P43/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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