发明名称 |
1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
摘要 |
<p>The present invention is directed to novel 1,1 -(dimethyl-ethylamino)-2- hydroxy-propoxy]-ethyl}-3-methyl-biphenyl-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof of structural formula I wherein the variable R1 is as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.</p> |
申请公布号 |
WO2010103429(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
WO2010IB50911 |
申请日期 |
2010.03.03 |
申请人 |
PFIZER INC.;HUMPHRIES, PAUL, STUART;PRICE, DAVID, ANTHONY |
发明人 |
HUMPHRIES, PAUL, STUART;PRICE, DAVID, ANTHONY |
分类号 |
C07C217/28;A61K31/192;A61P19/00;A61P29/00;C07C323/32 |
主分类号 |
C07C217/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|