发明名称 |
PHARMACEUTICALS AND METHODS FOR TREATING HYPOXIA AND SCREENING METHODS THEREFOR |
摘要 |
Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is“turned on”only under such conditions.
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申请公布号 |
US2010233735(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
US20080190987 |
申请日期 |
2008.08.13 |
申请人 |
DANA FARBER CANCER INSTITUTE |
发明人 |
KAELIN, JR. WILLIAM G.;IVAN MIRCEA |
分类号 |
G01N33/53;A61K31/7088;A61K38/00;A61K38/02;A61K38/44;A61K45/00;A61K48/00;A61P3/10;A61P7/02;A61P7/12;A61P9/00;A61P9/10;A61P11/00;A61P13/00;A61P13/12;A61P25/00;A61P35/00;C07K14/47;C12N15/09;C12Q1/02;C12Q1/25;C12Q1/26;G01N21/76;G01N33/15;G01N33/50;G01N33/542;G01N33/573 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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