发明名称 |
METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS |
摘要 |
The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a &bgr;-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride. |
申请公布号 |
US2010234564(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
US20080675777 |
申请日期 |
2008.08.27 |
申请人 |
DONG ZHENG XIN;EYNON JOHN S |
发明人 |
DONG ZHENG XIN;EYNON JOHN S. |
分类号 |
C07K5/083;C07K1/06 |
主分类号 |
C07K5/083 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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