发明名称 |
Nucleoside Aryl Phosphoramidates for the Treatment of RNA-Dependent RNA Viral Infection |
摘要 |
The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.
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申请公布号 |
US2010234316(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
US20070223940 |
申请日期 |
2007.02.12 |
申请人 |
MACCOSS MALCOLM;OLSEN DAVID B;DONGHI MONICA;GARDELLI CRISTINA;HARPER STEVEN;MEPPEN MALTE;NARJES FRANK;PACINI BARBARA |
发明人 |
MACCOSS MALCOLM;OLSEN DAVID B.;DONGHI MONICA;GARDELLI CRISTINA;HARPER STEVEN;MEPPEN MALTE;NARJES FRANK;PACINI BARBARA |
分类号 |
A61K31/7068;A61P31/14;C07H19/10 |
主分类号 |
A61K31/7068 |
代理机构 |
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