MONOCLONAL ANTIBODIES AND BINDING FRAGMENTS THEREOF DIRECTED TO THE MELANOCORTIN-4 RECEPTOR AND THEIR USE IN THE TREATMENT OF CACHEXIA AND RELATED CONDITIONS AND DISEASES

摘要

Disclosed are monoclonal antibodies, binding fragments, and derivatives thereof directed to the human melanocortin-4 receptor, as well as pharmaceutical compositions including the same, and therapeutic uses, including methods for treating cachexia and related conditions and diseases, using such monoclonal antibodies, binding fragments, derivatives, and pharmaceutical compositions.