发明名称 |
THERAPEUTIC AGENT FOR PRURITUS |
摘要 |
The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus. |
申请公布号 |
KR20100100935(A) |
申请公布日期 |
2010.09.15 |
申请号 |
KR20107014699 |
申请日期 |
2008.12.05 |
申请人 |
CHUGAI SEIYAKU KABUSHIKIKAISHA |
发明人 |
HIGUCHI YOSHINOBU;KASUTANI KEIKO;KITAMURA HIDETOMO;HASEGAWA MASAKAZU |
分类号 |
A61K39/395;A61K38/17;A61P17/00;A61P17/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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