P53 wild-type as biomarker for the treatment with mtor inhibitors in combination with a cytotoxic agent
摘要
<p>Provided are biomarkers for determining the sensitivity of proliferation diseases such as cancer to therapeutic agents, in particular mTOR inhibitors in combination with a cytotoxic agent, in particular a cytotoxic agent which damages or affects the integrity of DNA.</p>
申请公布号
EP2228452(A1)
申请公布日期
2010.09.15
申请号
EP20090173161
申请日期
2005.02.22
申请人
NOVARTIS AG;NOVARTIS PHARMA GMBH;NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
发明人
BEUVINK, IWAN;BOULAY, ANNE;LANE, HEIDI;O'REILLY, TERENCE;THOMAS, GEORGE
