发明名称 |
VACCINE COMPRISING MONOCYTE OR IMMATURE MYELOID CELLS(IMC) WHICH WERE LOADED WITH THE LIGAND OF NATURAL KILLER T CELL AND ANTIGEN |
摘要 |
The present invention relates to an immuno-therapeutic and prophylactic vaccine comprising monocytes or immature myeloid cells (IMCs) loaded with the ligand of natural killer T cell and an antigen for the prevention and treatment of infectious disease or cancer, more precisely, an immuno-therapeutic and prophylactic vaccine comprising monocytes or IMCs loaded with alpha-galactosylceramide (alphaGalCer), a kind of glycolipid and a natural killer T cell ligand, and antigen. Monocytes or immature myeloid cells (IMCs) therein, which are easily obtainable, unlike dendritic cells, not only induce a significant level of cytotoxic T lymphocyte responses but also have a prophylactic and therapeutic effect on malignant tumor. Therefore, the immuno-therapeutic and prophylactic vaccine of the present invention can be effectively used as an immunotherapeutic agent. |
申请公布号 |
EP2227253(A1) |
申请公布日期 |
2010.09.15 |
申请号 |
EP20070834349 |
申请日期 |
2007.11.28 |
申请人 |
SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION |
发明人 |
KANG, CHANG-YUIL;KO, HYUN-JEONG;LEE, JUNG-MI;KIM, YEON-JEONG |
分类号 |
A61K39/395;A61K39/00;A61K48/00;C07K14/31;C07K14/715;C07K16/32;C12N5/07 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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